RT Journal Article
SR Electronic
T1 A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1645
OP 1650
DO 10.1136/annrheumdis-2015-207499
VO 74
IS 9
A1 Benjamin A Fisher
A1 Rachel M Brown
A1 Simon J Bowman
A1 Francesca Barone
YR 2015
UL http://ard.bmj.com/content/74/9/1645.abstract
AB Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sjögren's syndrome (PSS) and were first described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and stratification, yet difficulties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for stratification and response to therapy and highlight areas where further validation work is required.