TY - JOUR T1 - A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1645 LP - 1650 DO - 10.1136/annrheumdis-2015-207499 VL - 74 IS - 9 AU - Benjamin A Fisher AU - Rachel M Brown AU - Simon J Bowman AU - Francesca Barone Y1 - 2015/09/01 UR - http://ard.bmj.com/content/74/9/1645.abstract N2 - Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sjögren's syndrome (PSS) and were first described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and stratification, yet difficulties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for stratification and response to therapy and highlight areas where further validation work is required. ER -