TY - JOUR T1 - PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1882 LP - 1885 DO - 10.1136/annrheumdis-2014-207187 VL - 74 IS - 10 AU - John Bowes AU - Sabine Loehr AU - Ashley Budu-Aggrey AU - Steffen Uebe AU - Ian N Bruce AU - Marie Feletar AU - Helena Marzo-Ortega AU - Philip Helliwell AU - Anthony W Ryan AU - David Kane AU - Eleanor Korendowych AU - Gerd-Marie Alenius AU - Emiliano Giardina AU - Jonathan Packham AU - Ross McManus AU - Oliver FitzGerald AU - Matthew A Brown AU - Frank Behrens AU - Harald Burkhardt AU - Neil McHugh AU - Ulrike Huffmeier AU - Pauline Ho AU - Andre Reis AU - Anne Barton Y1 - 2015/10/01 UR - http://ard.bmj.com/content/74/10/1882.abstract N2 - Objectives Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.Methods A total of 15 single nucleotide polymorphisms were selected (PImmunochip <1×10−4) for validation genotyping in 1177 cases and 2155 controls using TaqMan. Meta-analysis of Immunochip and validation data sets consisted of 3139 PsA cases and 11 078 controls. Novel PsA susceptibility loci were compared with data from two large psoriasis studies (WTCCC2 and Immunochip) to determine PsA specificity.Results We found genome-wide significant association to rs2476601, mapping to PTPN22 (p=1.49×10−9, OR=1.32), but no evidence for association in the psoriasis cohort (p=0.34) and the effect estimates were significantly different between PsA and psoriasis (p=3.2×10−4). Additionally, we found genome-wide significant association to the previously reported psoriasis risk loci; NOS2 (rs4795067, p=5.27×10−9).Conclusions For the first time, we report genome-wide significant association of PTPN22 (rs2476601) to PsA susceptibility, but no evidence for association to psoriasis. ER -