TY - JOUR T1 - The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1854 LP - 1860 DO - 10.1136/annrheumdis-2014-205372 VL - 74 IS - 10 AU - Jaime Guzman AU - Kiem Oen AU - Lori B Tucker AU - Adam M Huber AU - Natalie Shiff AU - Gilles Boire AU - Rosie Scuccimarri AU - Roberta Berard AU - Shirley M L Tse AU - Kimberly Morishita AU - Elizabeth Stringer AU - Nicole Johnson AU - Deborah M Levy AU - Karen Watanabe Duffy AU - David A Cabral AU - Alan M Rosenberg AU - Maggie Larché AU - Paul Dancey AU - Ross E Petty AU - Ronald M Laxer AU - Earl Silverman AU - Paivi Miettunen AU - Anne-Laure Chetaille AU - Elie Haddad AU - Kristin Houghton AU - Lynn Spiegel AU - Stuart E Turvey AU - Heinrike Schmeling AU - Bianca Lang AU - Janet Ellsworth AU - Suzanne Ramsey AU - Alessandra Bruns AU - Sarah Campillo AU - Susanne Benseler AU - Gaëlle Chédeville AU - Rayfel Schneider AU - Rae Yeung AU - Ciarán M Duffy Y1 - 2015/10/01 UR - http://ard.bmj.com/content/74/10/1854.abstract N2 - Objective To describe clinical outcomes of juvenile idiopathic arthritis (JIA) in a prospective inception cohort of children managed with contemporary treatments.Methods Children newly diagnosed with JIA at 16 Canadian paediatric rheumatology centres from 2005 to 2010 were included. Kaplan–Meier survival curves for each JIA category were used to estimate probability of ever attaining an active joint count of 0, inactive disease (no active joints, no extraarticular manifestations and a physician global assessment of disease activity <10 mm), disease remission (inactive disease >12 months after discontinuing treatment) and of receiving specific treatments.Results In a cohort of 1104 children, the probabilities of attaining an active joint count of 0 exceeded 78% within 2 years in all JIA categories. The probability of attaining inactive disease exceeded 70% within 2 years in all categories, except for RF-positive polyarthritis (48%). The probability of discontinuing treatment at least once was 67% within 5 years. The probability of attaining remission within 5 years was 46–57% across JIA categories except for polyarthritis (0% RF-positive, 14% RF-negative). Initial treatment included joint injections and non-steroidal anti-inflammatory drugs for oligoarthritis, disease-modifying antirheumatic drugs (DMARDs) for polyarthritis and systemic corticosteroids for systemic JIA.Conclusions Most children with JIA managed with contemporary treatments attain inactive disease within 2 years of diagnosis and many are able to discontinue treatment. The probability of attaining remission within 5 years of diagnosis is about 50%, except for children with polyarthritis. ER -