TY - JOUR T1 - Response to: ‘Is primary Sjögren's syndrome an orphan disease? A critical appraisal of prevalence studies in Europe’ by Cornec and Chiche JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - e26 LP - e26 DO - 10.1136/annrheumdis-2014-206885 VL - 74 IS - 3 AU - Baodong Qin AU - Jiaqi Wang AU - Zaixing Yang AU - Yan Liang AU - Renqiang Zhong Y1 - 2015/03/01 UR - http://ard.bmj.com/content/74/3/e26.abstract N2 - We thank Divi Cornec and Laurent Chiche1 for their valuable comments on our article.2 We think that the majority of remarks they made were reasonable and helpful for a deep understanding of the prevalence of primary Sjögren's syndrome (pSS). Due to the great differences between a population-based study and sample survey, it is obvious that a high heterogeneity (p<0.001 for Q statistic, I2=98.95%) could be observed across these articles when conducting a meta-analysis. According to the definition of a rare disease, the total prevalence rate from our study did show that pSS is not a rare disease (one case in 1644). But the prevalence rate was one case per 2304 persons when only considering a population-based study, suggesting pSS is a rare disease.Among the included studies in our paper, pSS … ER -