PT  - JOURNAL ARTICLE
AU  - Ogdie, Alexis
AU  - Yu, YiDing
AU  - Haynes, Kevin
AU  - Love, Thorvardur Jon
AU  - Maliha, Samantha
AU  - Jiang, Yihui
AU  - Troxel, Andrea B
AU  - Hennessy, Sean
AU  - Kimmel, Steven E
AU  - Margolis, David J
AU  - Choi, Hyon
AU  - Mehta, Nehal N
AU  - Gelfand, Joel M
TI  - Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study
AID  - 10.1136/annrheumdis-2014-205675
DP  - 2015 Feb 01
TA  - Annals of the Rheumatic Diseases
PG  - 326--332
VI  - 74
IP  - 2
4099  - http://ard.bmj.com/content/74/2/326.short
4100  - http://ard.bmj.com/content/74/2/326.full
SO  - Ann Rheum Dis2015 Feb 01; 74
AB  - Objectives We aimed to quantify the risk of major adverse cardiovascular events (MACE) among patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA) and psoriasis without known PsA compared with the general population after adjusting for traditional cardiovascular risk factors.Methods A population-based longitudinal cohort study from 1994 to 2010 was performed in The Health Improvement Network (THIN), a primary care medical record database in the UK. Patients aged 18–89 years of age with PsA, RA or psoriasis were included. Up to 10 unexposed controls matched on practice and index date were selected for each patient with PsA. Outcomes included cardiovascular death, myocardial infarction, cerebrovascular accidents and the composite outcome (MACE). Cox proportional hazards models were used to calculate the HRs for each outcome adjusted for traditional risk factors. A priori, we hypothesised an interaction between disease status and disease-modifying antirheumatic drug (DMARD) use.Results Patients with PsA (N=8706), RA (N=41 752), psoriasis (N=138 424) and unexposed controls (N=81 573) were identified. After adjustment for traditional risk factors, the risk of MACE was higher in patients with PsA not prescribed a DMARD (HR 1.24, 95% CI 1.03 to 1.49), patients with RA (No DMARD: HR 1.39, 95% CI 1.28 to 1.50, DMARD: HR 1.58, 95% CI 1.46 to 1.70), patients with psoriasis not prescribed a DMARD (HR 1.08, 95% CI 1.02 to 1.15) and patients with severe psoriasis (DMARD users: HR 1.42, 95% CI 1.17 to 1.73).Conclusions Cardiovascular risk should be addressed with all patients affected by psoriasis, PsA or RA.