TY - JOUR T1 - High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - e13 LP - e13 DO - 10.1136/annrheumdis-2013-204749 VL - 74 IS - 3 AU - Kwangwoo Kim AU - So-Young Bang AU - Hye-Soon Lee AU - Soo-Kyung Cho AU - Chan-Bum Choi AU - Yoon-Kyoung Sung AU - Tae-Hwan Kim AU - Jae-Bum Jun AU - Dae Hyun Yoo AU - Young Mo Kang AU - Seong-Kyu Kim AU - Chang-Hee Suh AU - Seung-Cheol Shim AU - Shin-Seok Lee AU - Jisoo Lee AU - Won Tae Chung AU - Jung-Yoon Choe AU - Hyoung Doo Shin AU - Jong-Young Lee AU - Bok-Ghee Han AU - Swapan K Nath AU - Steve Eyre AU - John Bowes AU - Dimitrios A Pappas AU - Joel M Kremer AU - Miguel A Gonzalez-Gay AU - Luis Rodriguez-Rodriguez AU - Lisbeth Ärlestig AU - Yukinori Okada AU - Dorothée Diogo AU - Katherine P Liao AU - Elizabeth W Karlson AU - Soumya Raychaudhuri AU - Solbritt Rantapää-Dahlqvist AU - Javier Martin AU - Lars Klareskog AU - Leonid Padyukov AU - Peter K Gregersen AU - Jane Worthington AU - Jeffrey D Greenberg AU - Robert M Plenge AU - Sang-Cheol Bae Y1 - 2015/03/01 UR - http://ard.bmj.com/content/74/3/e13.abstract N2 - Objective A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. Methods We analysed Korean rheumatoid arthritis case–control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case–control samples. Results We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1–FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p<5×10−8), with evidence for three independent risk alleles at 1q25/TNFSF4. The risk alleles from the seven new loci except for the TNFSF4 locus (monomorphic in Koreans), together with risk alleles from previously established RA risk loci, exhibited a high correlation of effect sizes between ancestries. Further, we refined the number of single nucleotide polymorphisms (SNPs) that represent potentially causal variants through a trans-ethnic comparison of densely genotyped SNPs. Conclusions This study demonstrates the advantage of dense-mapping and trans-ancestral analysis for identification of potentially causal SNPs. In addition, our findings support the importance of T cells in the pathogenesis and the fact of frequent overlap of risk loci among diverse autoimmune diseases. ER -