RT Journal Article
SR Electronic
T1 SAT0202 Early Accrual of Organ Damage in Systemic Sclerosis: Rationale for Forming a Multinational Inception Cohort of Patients with Scleroderma (The Insync Study)
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP A649
OP A649
DO 10.1136/annrheumdis-2013-eular.1928
VO 72
IS Suppl 3
A1 M. Nikpour
A1 M. Baron
A1 M. Hudson
A1 P. Carreira
A1 N. Hunzelmann
A1 T. Frech
A1 J. Sahhar
A1 P. Nash
A1 J. Roddy
A1 L. Schrieber
A1 W. Stevens
A1 S. Proudman
YR 2013
UL http://ard.bmj.com/content/72/Suppl_3/A649.1.abstract
AB Background Systemic sclerosis (SSc) has the potential to result in irreversible damage in various organs. Objectives To determine the accrual of damage in each organ system in the first five years of SSc disease. Methods A panel of experts defined organ-specific indicators of damage in SSc. Using prospectively acquired data from patients entering the Australian Scleroderma Cohort Study within 2 years of disease onset, annual accrual of organ damage from years 2 to 5 following disease onset was determined. Results The frequency of each damage indicator at years 2 to 5 in 182 patients is presented in the graph. Damage occurred in all organ systems, most commonly in the skin/MSK (23.1% at 4 years), respiratory (12.1%), GI (7.1%) & GU systems (erectile dysfunction in men 31.4%). Conclusions Organ damage occurs early in SSc. This is a compelling rationale for forming a large inception cohort (INternational SYstemic Sclerosis Inception Cohort; INSYNC) of patients with SSc to determine the predictors of organ damage and to develop strategies for preventing the occurrence of organ damage in SSc. Disclosure of Interest None Declared