PT  - JOURNAL ARTICLE
AU  - Suzanne M M Verstappen
AU  - Mark Lunt
AU  - Robert N Luben
AU  - Jackie Chipping
AU  - Tarnya Marshall
AU  - Kay-Tee Khaw
AU  - Nick Wareham
AU  - William G Dixon
AU  - Ian N Bruce
AU  - Deborah P M Symmons
TI  - Demographic and disease-related predictors of abnormal lung function in patients with established inflammatory polyarthritis and a comparison with the general population
AID  - 10.1136/annrheumdis-2012-201698
DP  - 2013 Sep 01
TA  - Annals of the Rheumatic Diseases
PG  - 1517--1523
VI  - 72
IP  - 9
4099  - http://ard.bmj.com/content/72/9/1517.short
4100  - http://ard.bmj.com/content/72/9/1517.full
SO  - Ann Rheum Dis2013 Sep 01; 72
AB  - Objectives To identify demographic and clinical predictors of obstructive lung disease (OLD) and restrictive lung disease (RLD) in patients with established inflammatory polyarthritis (IP) and to compare the prevalence of respiratory symptoms in patients with IP and the general population. Method A total of 421 patients with IP underwent a spirometry test 15 years after inclusion in the Norfolk Arthritis Register (NOAR). Logistic regression analyses were performed to assess the predictive ability of demographic and clinical characteristics obtained at inclusion in NOAR and to assess their association with OLD or RLD at 15 years (age- and gender-adjusted). In addition, the prevalence of OLD and RLD was compared with a matched population (1:4) of people participating in the European Prospective Investigation of Cancer-Norfolk, a representative sample of the general population in Norfolk, UK. Results In this IP population, current smoking was the strongest predictor for OLD and functional disability for RLD. In the comparison study, 11.6% had OLD in the IP population and 4.9% in the general population (adjOR 2.01, 95% CI 1.26 to 3.22). The prevalence of RLD was not statistically different between the IP population and the general population (14.6% vs 17.5%; adjOR 0.76, 95% CI 0.53 to 1.10). Conclusions OLD, but not RLD, is more prevalent in the IP population than in the general population. Functional disability is especially associated with RLD whereas smoking is associated with OLD. The latter finding, and the known association between smoking and a poor disease prognosis, underlines the importance of smoking cessation in patients with IP.