RT Journal Article
SR Electronic
T1 EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 479
OP 481
DO 10.1136/annrheumdis-2012-202779
VO 72
IS 4
A1 Désirée van der Heijde
A1 Annette H M van der Helm-van Mil
A1 Daniel Aletaha
A1 Clifton O Bingham
A1 Gerd R Burmester
A1 Maxime Dougados
A1 Paul Emery
A1 David Felson
A1 Rachel Knevel
A1 Tore K Kvien
A1 Robert B M Landewé
A1 Cédric Lukas
A1 Iain McInnes
A1 Alan J Silman
A1 Josef S Smolen
A1 Ewa Stanislawska-Biernat
A1 Angela Zink
A1 Bernard Combe
YR 2013
UL http://ard.bmj.com/content/72/4/479.abstract
AB The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR task force was formed including 16 rheumatologists and one rheumatology fellow. The process was both evidence based and consensus based, and included, between March 2010 and April 2012, analyses of data from two cohorts, two face-to-face meetings, one online voting and one teleconference. The Leiden Early Arthritis Cohort and the French ESPOIR cohort were used for the evidence-based part. The outcome measures, which were initiation of methotrexate therapy, or any disease-modifying antirheumatic drug therapy within the first year of disease and arthritis persistency over 5 years, were studied with the aim to give the best definition of erosive disease. A decision was made to select a definition with a high specificity and focus on patients who did not otherwise fulfil the 2010 ACR/EULAR RA criteria (<6 points). By a unanimous vote the following definition was selected: erosive disease for use in the 2010 ACR/EULAR RA classification criteria is defined when an erosion (defined as a cortical break) is seen in at least three separate joints at any of the following sites: the proximal interphalangeal, the metacarpophalangeal, the wrist (counted as one joint) and the metatarsophalangeal joints on radiographs of both hands and feet. A highly specific definition for erosive disease has thus been formulated.