TY - JOUR T1 - Deletion of <em>LCE3C_LCE3B</em> is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1648 LP - 1651 DO - 10.1136/ard.2010.148072 VL - 70 IS - 9 AU - Xiaolan Lu AU - Jianping Guo AU - Xujie Zhou AU - Ru Li AU - Xia Liu AU - Yi Zhao AU - Baoli Zhu AU - Xiangyuan Liu AU - Jianhua Xu AU - Ping Zhu AU - Xinyu Wu AU - Jing He AU - Xu Liu AU - Hong Zhang AU - Zhanguo Li Y1 - 2011/09/01 UR - http://ard.bmj.com/content/70/9/1648.abstract N2 - Objectives The deletion of LCE3C_LCE3B confers susceptibility to psoriasis and rheumatoid arthritis (RA) in Caucasians. The aim of this study was to investigate the variant involvement in RA in the Chinese Han population and to further explore its potential role in the susceptibility to systemic lupus erythematosus (SLE). Methods LCE3C_LCE3B-del was genotyped in 898 patients with RA and 681 healthy controls. Two single nucleotide polymorphisms (SNPs, rs4112788 and rs4085613) in strong linkage disequilibrium with LCE3C_LCE3B-del were then genotyped in patients with RA (n=1222), SLE (n=870) and healthy controls (n=1031). Results The deletion of LCE3C_LCE3B and SNPs rs4112788 and rs4085613 showed an association with RA (allele analysis: p=7.72×10−4, OR 1.28, 95% CI 1.11 to 1.47; p=6.39×10−4, OR 1.23, 95% CI 1.09 to 1.38; and p=5.38×10−4, OR 1.23, 95% CI 1.10 to 1.39, respectively). The two SNPs were also significantly associated with SLE (allele analysis: p=7.68×10−3, OR 1.19, 95% CI 1.05 to 1.36 and p=5.30×10−3, OR 1.20, 95% CI 1.06 to 1.37). Conclusions This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE. ER -