PT  - JOURNAL ARTICLE
AU  - Siok Hoon Lily Lim
AU  - Susanne M Benseler
AU  - Pascal N Tyrrell
AU  - Martin Charron
AU  - Elizabeth Harvey
AU  - Diane Hebert
AU  - Earl D Silverman
TI  - Low bone mineral density is present in newly diagnosed paediatric systemic lupus erythematosus patients
AID  - 10.1136/ard.2010.144311
DP  - 2011 Nov 01
TA  - Annals of the Rheumatic Diseases
PG  - 1991--1994
VI  - 70
IP  - 11
4099  - http://ard.bmj.com/content/70/11/1991.short
4100  - http://ard.bmj.com/content/70/11/1991.full
SO  - Ann Rheum Dis2011 Nov 01; 70
AB  - Objectives The objectives of this study were to (1) determine the prevalence of low bone mineral density (BMD) in a large prospective cohort of newly diagnosed patients with paediatric systemic lupus erythematosus (pSLE) and (2) identify risk factors associated with low BMD. Methods Single-centre cohort study of 80 children and adolescents who underwent a dual-energy x-ray absorptiometry within 3 months of diagnosis. Low lumbar spine (LS) BMD was defined as z score ≤−2.0. BMD was correlated with baseline demographic, clinical and laboratory markers of disease activity and biochemical markers of bone health. Risk factors of BMD were evaluated with univariable and multivariable linear and logistic regression analyses. Results Low BMD at any site was found in 15% of newly diagnosed pSLE patients. LS BMD was associated with body mass index (BMI) z score and corrected calcium (r2=0.31, p<0.0001). Hip BMD was associated with BMI z score and intact parathyroid hormone (iPTH) (r2=0.26, p=0.002). Higher BMI z score was protective against low BMD at any site (OR 0.35). Conclusions One in six newly diagnosed pSLE patients had low BMD (at any site). Low BMI z score, low calcium and high iPTH identified children at risk for low BMD at diagnosis of pSLE.