RT Journal Article
SR Electronic
T1 Animal models for arthritis: innovative tools for prevention and treatment
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1357
OP 1362
DO 10.1136/ard.2010.148551
VO 70
IS 8
A1 George Kollias
A1 Piyi Papadaki
A1 Florence Apparailly
A1 Margriet J Vervoordeldonk
A1 Rikard Holmdahl
A1 Vera Baumans
A1 Christian Desaintes
A1 James Di Santo
A1 Jörg Distler
A1 Paul Garside
A1 Martin Hegen
A1 Tom W J Huizinga
A1 Astrid Jüngel
A1 Lars Klareskog
A1 Iain McInnes
A1 Ioannis Ragoussis
A1 Georg Schett
A1 Bert ‘t Hart
A1 Paul P Tak
A1 Rene Toes
A1 Wim van den Berg
A1 Wolfgang Wurst
A1 Steffen Gay
YR 2011
UL http://ard.bmj.com/content/70/8/1357.abstract
AB The development of novel treatments for rheumatoid arthritis (RA) requires the interplay between clinical observations and studies in animal models. Given the complex molecular pathogenesis and highly heterogeneous clinical picture of RA, there is an urgent need to dissect its multifactorial nature and to propose new strategies for preventive, early and curative treatments. Research on animal models has generated new knowledge on RA pathophysiology and aetiology and has provided highly successful paradigms for innovative drug development. Recent focus has shifted towards the discovery of novel biomarkers, with emphasis on presymptomatic and emerging stages of human RA, and towards addressing the pathophysiological mechanisms and subsequent efficacy of interventions that underlie different disease variants. Shifts in the current paradigms underlying RA pathogenesis have also led to increased demand for new (including humanised) animal models. There is therefore an urgent need to integrate the knowledge on human and animal models with the ultimate goal of creating a comprehensive ‘pathogenesis map’ that will guide alignment of existing and new animal models to the subset of disease they mimic. This requires full and standardised characterisation of all models at the genotypic, phenotypic and biomarker level, exploiting recent technological developments in ‘omics’ profiling and computational biology as well as state of the art bioimaging. Efficient integration and dissemination of information and resources as well as outreach to the public will be necessary to manage the plethora of data accumulated and to increase community awareness and support for innovative animal model research in rheumatology.