TY - JOUR T1 - Upregulated SUMO-2/3 expression is involved in the regulation of apoptosis and matrix metalloproteinase expression in rheumatoid arthritis synovial fibroblasts JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - A30 LP - A30 DO - 10.1136/ard.2010.129619h VL - 69 IS - Suppl 2 AU - S Frank AU - S Strietholt AU - C Wunrau AU - T Pap AU - M A Peters Y1 - 2010/03/01 UR - http://ard.bmj.com/content/69/Suppl_2/A30.2.abstract N2 - SUMO-2/3 belongs to the small ubiquitin-related modifier family of proteins that have been implicated in many biological functions such as intracellular protein transport, control of gene expression and stability of proteins. The authors have previously shown that elevated expression of SUMO-1 in rheumatoid arthritis (RA) synovial fibroblasts (RASF) confers the resistance against Fas-induced apoptosis through SUMO-1/SENP1-dependent mechanisms. Based on these findings, the authors set out to analyse the expression of SUMO-2/3 in human RA and in a tumour necrosis … ER -