TY - JOUR T1 - Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1733 LP - 1734 DO - 10.1136/ard.2009.125732 VL - 69 IS - 9 AU - Federica Corallini AU - Paola Secchiero AU - Gabriella Castellino AU - Maurizio Montecucco AU - Francesco Trotta AU - Giorgio Zauli Y1 - 2010/09/01 UR - http://ard.bmj.com/content/69/9/1733.abstract N2 - Products of the secreted frizzled-related protein (FRZB) families have crucial roles in the development and maintenance of bone, cartilage and joints, mainly by inhibiting the wnt and/β catenin pathway.1 In particular, while several important studies have associated FRZB (also known as sFRP3) with an increased susceptibility to the development of osteoarthritis,2,–,4 no information is available on the potential role of circulating FRZB in early rheumatoid arthritis (ERA).We have measured the serum levels of FRZB by ELISA (R&D Systems, Minneapolis, Minnesota, USA) in a cohort of patients presenting with ERA, defined as previously described.5 Serological signs of inflammation (raised erythrocyte sedimentation rate or C reactive … ER -