TY - JOUR T1 - TNFα blockade impairs T cell dependent humoural responses JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - A13 LP - A13 DO - 10.1136/ard.2010.129585f VL - 69 IS - Suppl 2 AU - G F Salinas AU - L De Rycke AU - T Cantaert AU - M van de Burg AU - B Barendregt AU - P Remans AU - P Peter Tak AU - D Baeten Y1 - 2010/03/01 UR - http://ard.bmj.com/content/69/Suppl_2/A13.1.abstract N2 - Tumour necrosis factor α (TNFα) blockade in spondyloarthritis (SpA) induces antibodies specific for double stranded DNA, which is a T cell independent (TI) antigen. As these antibodies were restricted to the IgM isotype and no antibodies to T cell dependent (TD) antigens were induced, we investigated here if TNF blockade impairs the induction and maturation of TD humoural responses. 30 SpA patients (20 treated … ER -