RT Journal Article
SR Electronic
T1 Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 423
OP 427
DO 10.1136/ard.2010.139550
VO 70
IS 3
A1 van de Sande, Marleen G H
A1 Gerlag, Danielle M
A1 Lodde, Beatrijs M
A1 van Baarsen, Lisa G M
A1 Alivernini, Stefano
A1 Codullo, Veronica
A1 Felea, Ioana
A1 Vieira-Sousa, Elsa
A1 Fearon, Ursula
A1 Reece, Richard
A1 Montecucco, Carlomaurizio
A1 Veale, Douglas J
A1 Pitzalis, Costantino
A1 Emery, Paul
A1 Klareskog, Lars
A1 McInnes, Iain B
A1 Tak, Paul P
YR 2011
UL http://ard.bmj.com/content/70/3/423.abstract
AB Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.