TY - JOUR T1 - Successful treatment of adult-onset Still's disease refractory to TNF and IL-1 blockade by IL-6 receptor blockade JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 390 LP - 392 DO - 10.1136/ard.2010.129403 VL - 70 IS - 2 AU - Juergen Rech AU - Monika Ronneberger AU - Matthias Englbrecht AU - Stephanie Finzel AU - Julia Katzenbeisser AU - Karin Manger AU - Bernhard Manger AU - Georg Schett Y1 - 2011/02/01 UR - http://ard.bmj.com/content/70/2/390.abstract N2 - Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown aetiology.1 Based on the substantial acute phase responses observed in AOSD, we hypothesised that blockade of the interleukin 6R (IL-6R), neutralising the induction of the acute phase response by IL-6, could be a useful treatment in multidrug-resistant AOSD. We here report on three patients with AOSD who were refractory to standard treatment and cytokine blockade with anakinra and tumour necrosis factor (TNF) blockers and were subjected to treatment with tocilizumab. The characteristics of these three patients are summarised in table 1.View this table:In this windowIn a new windowTable 1 Characteristics of patients A 19-year-old woman was first diagnosed with AOSD in July 2006. Prednisone therapy was started, but multiple relapses occurred during the following 2 years requiring … ER -