PT  - JOURNAL ARTICLE
AU  - L Gossec
AU  - M Dougados
AU  - N Rincheval
AU  - A Balanescu
AU  - D T Boumpas
AU  - S Canadelo
AU  - L Carmona
AU  - J-P Daurès
AU  - M de Wit
AU  - B A C Dijkmans
AU  - M Englbrecht
AU  - Z Gunendi
AU  - T Heiberg
AU  - J R Kirwan
AU  - E M Mola
AU  - M Matucci-Cerinic
AU  - K Otsa
AU  - G Schett
AU  - T Sokka
AU  - G A Wells
AU  - G J Aanerud
AU  - A Celano
AU  - A Dudkin
AU  - C Hernandez
AU  - K Koutsogianni
AU  - F N Akca
AU  - A-M Petre
AU  - P Richards
AU  - M Scholte-Voshaar
AU  - G Von Krause
AU  - T K Kvien
TI  - Elaboration of the preliminary Rheumatoid Arthritis Impact of Disease (RAID) score: a EULAR initiative
AID  - 10.1136/ard.2008.100271
DP  - 2009 Nov 01
TA  - Annals of the Rheumatic Diseases
PG  - 1680--1685
VI  - 68
IP  - 11
4099  - http://ard.bmj.com/content/68/11/1680.short
4100  - http://ard.bmj.com/content/68/11/1680.full
SO  - Ann Rheum Dis2009 Nov 01; 68
AB  - Background: Current response criteria in rheumatoid arthritis (RA) usually assess only three patient-reported outcomes (PROs): pain, functional disability and patient global assessment. Other important PROs such as fatigue are not included.Objective: To elaborate a patient-derived composite response index for use in clinical trials in RA, the RA Impact of Disease (RAID) score.Methods: Ten patients identified 17 domains or areas of health relevant for inclusion in the score, then 96 patients (10 per country in 10 European countries) ranked these domains in order of decreasing importance. The seven most important domains were selected. Instruments were chosen for each domain after extensive literature research of psychometric properties and expert opinion. The relative weight of each of the domains was obtained from 505 patients who were asked to “distribute 100 points” among the seven domains. The average ranks of importance of these domains were then computed.Results: The RAID score includes seven domains with the following relative weights: pain (21%), functional disability (16%), fatigue (15%), emotional well-being (12%), sleep (12%), coping (12%) and physical well-being (12%). Weights were similar across countries and across patient and disease characteristics. Proposed instruments include the Health Assessment Questionnaire and numerical ratings scales.Conclusion: The preliminary RAID score is a patient-derived weighted score to assess the impact of RA. An ongoing study will allow the final choice of questionnaires and assessment of validity. This score can be used in clinical trials as a new composite index that captures information relevant to patients.