PT  - JOURNAL ARTICLE
AU  - Allenbach, Y
AU  - Seror, R
AU  - Pagnoux, C
AU  - Teixeira, L
AU  - Guilpain, P
AU  - Guillevin, L
AU  - ,
TI  - High frequency of venous thromboembolic events in Churg–Strauss syndrome, Wegener’s granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients
AID  - 10.1136/ard.2008.099051
DP  - 2009 Apr 01
TA  - Annals of the Rheumatic Diseases
PG  - 564--567
VI  - 68
IP  - 4
4099  - http://ard.bmj.com/content/68/4/564.short
4100  - http://ard.bmj.com/content/68/4/564.full
SO  - Ann Rheum Dis2009 Apr 01; 68
AB  - Objective: To determine the frequency and risk factors of venous thromboembolic events (VTE) in Wegener’s granulomatosis (WG), microscopic polyangiitis (MPA) and, the so far unstudied, Churg–Strauss syndrome (CSS) and polyarteritis nodosa (PAN).Methods: Retrospective, systematic analysis and comparisons were made between the characteristics of patients in the VTE group and non-VTE group. 1130 patients with WG, MPA, CSS or PAN were identified from the French Vasculitis Study Group cohort.Results: During a mean follow-up of 58.4 (45.8) months, 83 VTE occurred in 74 (6.5%) patients, with a median vasculitis–VTE diagnosis interval of 5.8 months (−3 to +156). VTE occurred in seven of 285 (2.5%) patients with PAN, 19 of 232 (8.2%) with CSS, 30 of 377 (8%) with WG and 18 of 236 (7.6%) with MPA. Multivariate analysis retained age, male sex or previous VTE or stroke with motor deficit as being associated with a higher VTE risk. The adjusted odds ratio (95% confidence interval) for VTE was 2.88 (1.27 to 6.50) for patients with WG, MPA or CSS compared with PAN (p = 0.01).Conclusions: Our results suggest that, like WG and MPA, patients with CSS are at a greater risk of VTE, than those with PAN. The reasons for this difference remain to be elucidated.