TY - JOUR T1 - Lack of association between <em>PADI4</em> and functional severity in Japanese rheumatoid arthritis patients JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 431 LP - 432 DO - 10.1136/ard.2007.071084 VL - 67 IS - 3 AU - K Nishimoto AU - K Ikari AU - T Mochizuki AU - T Tomatsu AU - Y Toyama AU - M Hara AU - H Yamanaka AU - N Kamatani AU - S Momohara Y1 - 2008/03/01 UR - http://ard.bmj.com/content/67/3/431.abstract N2 - Clinical presentation of rheumatoid arthritis (RA) varies from mild deformity of small joints to mutilating severe arthritis causing remarkable functional disorder and restriction of daily life activities. Prediction of disease outcome may allow better targeting of aggressive treatment. Recently, anti-cyclic citrullinated peptide antibody (anti-CCP) has been reported to be associated with disease outcomes.1–5 Peptidylarginine deiminase type 4 (PADI4), encoding citrullinating enzyme, was identified as one of the RA susceptibility genes and was also reported to be associated with the level of anti-CCP in RA patients.6 These findings suggest the hypothesis that PADI4 determines disease severity of RA as well as its susceptibility. Our aim was to investigate the association between … ER -