PT  - JOURNAL ARTICLE
AU  - Baranathan, Vijay
AU  - Stanford, Miles R
AU  - Vaughan, Robert W
AU  - Kondeatis, Elli
AU  - Graham, Elizabeth
AU  - Fortune, Farida
AU  - Madanat, Wafa
AU  - Kanawati, Charlie
AU  - Ghabra, Marwen
AU  - Murray, Philip I
AU  - Wallace, Graham R
TI  - The association of the PTPN22 620W polymorphism with Behçet’s disease
AID  - 10.1136/ard.2007.073866
DP  - 2007 Nov 01
TA  - Annals of the Rheumatic Diseases
PG  - 1531--1533
VI  - 66
IP  - 11
4099  - http://ard.bmj.com/content/66/11/1531.short
4100  - http://ard.bmj.com/content/66/11/1531.full
SO  - Ann Rheum Dis2007 Nov 01; 66
AB  - Objectives: A single nucleotide polymorphism (SNP) of the gene encoding protein tyrosine phosphatase type 22 (PTPN22 620W) has recently been described as a strong common genetic risk factor for human autoimmune disease. We have analysed the association of PTPN22 620W in patients with Behçet’s disease (BD).Methods: Genomic DNA was obtained from 270 patients with BD from the UK and the Middle East. Normal controls (n  =  203) were collected from the same populations. Patients with idiopathic retinal vasculitis from the UK (n  =  136) were used as disease controls. PTPN22 620W was detected by SSP–PCR analysis and agarose gel electrophoresis.Results: The results showed an inverse correlation between the presence of PTPN22 620W and Behçet’s disease in either patient group tested. There was a greatly reduced prevalence in Middle Eastern compared to UK patients and controls. Finally, there was no association with either UK patients with retinal vasculitis compared with UK controls.Conclusions: The presence of PTPN22 620W was inversely associated with BD and the distribution of the SNP in the Middle East supports previous findings in the global prevalence.