TY - JOUR T1 - Endothelial nitric oxide synthase +894 polymorphism is associated with recurrent salivary gland swelling and early onset in patients with primary Sjögren’s syndrome JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1400 LP - 1401 DO - 10.1136/ard.2007.069385 VL - 66 IS - 10 AU - Marja Pertovaara AU - Jaakko Antonen AU - Mikko Hurme Y1 - 2007/10/01 UR - http://ard.bmj.com/content/66/10/1400.abstract N2 - Primary Sjögren’s syndrome (SS) is a chronic autoimmune disease that affects primarily the salivary and lacrimal glands. Nitric oxide (NO) has been implicated in the pathogenesis of SS and raised nitrite concentrations have been observed in the saliva of patients with SS.1 NO is a molecule that plays a key role in many physiological and pathological processes. It is produced in vivo from the aminoacid l-arginine by a family of nitric oxide synthases (NOS), of which three isoforms have been identified, i.e. neuronal, endothelial and inducible.2 Endothelial nitric oxide synthase (eNOS) is a constitutively expressed isoform of NOS. The eNOS gene entails several polymorphisms, of which for … ER -