TY - JOUR T1 - Reversal of Sjögren’s-like syndrome in non-obese diabetic mice JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 812 LP - 814 DO - 10.1136/ard.2006.064030 VL - 66 IS - 6 AU - Simon D Tran AU - Shohta Kodama AU - Beatrijs M Lodde AU - Ildiko Szalayova AU - Sharon Key AU - Saeed Khalili AU - Denise L Faustman AU - Éva Mezey Y1 - 2007/06/01 UR - http://ard.bmj.com/content/66/6/812.abstract N2 - Background: Non-obese diabetic (NOD) mice exhibit autoimmune diabetes and Sjögren’s-like syndrome.Objective: To test whether a treatment that reverses end-stage diabetes in the NOD mouse would affect their Sjögren’s-like syndrome.Methods: NOD mice have a proteasome defect. Improperly selected naive T cells escape, but can be killed by reintroducing major histocompatibility complex class I self-peptides on matched normal splenocytes. The proteasome defect also impairs nuclear factor kB, a transcription factor in pathogenic memory T cells, increasing their susceptibility to tumour necrosis factor-induced apoptosis stimulated through complete Freund’s adjuvant (CFA). The impact of this two-limb therapy (injections of matched normal splenocytes and CFA) on the autoimmune salivary gland disease of the NOD mice was studied.Results: All NOD mice receiving the above treatment had a complete recovery of salivary flow and were protected from diabetes. Restoration of salivary flow could be the result of a combination of rescue and regeneration of the gland, as confirmed by immunohistochemical analysis. All untreated NOD mice showed a continuous decline in salivary flow, followed by hyperglycaemia and death.Conclusion: This study establishes that a brief intervention in NOD mice with Sjögren’s-like syndrome can reverse salivary gland dysfunction. ER -