RT Journal Article
SR Electronic
T1 Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 144
OP 148
DO 10.1136/ard.2005.041673
VO 65
IS 2
A1 S Giannouli
A1 M Voulgarelis
A1 P D Ziakas
A1 A G Tzioufas
YR 2006
UL http://ard.bmj.com/content/65/2/144.abstract
AB Haematological abnormalities are common in systemic lupus erythematosus. Anaemia is found in about 50% of patients, with anaemia of chronic disease being the most common form. Impaired erythropoietin response and presence of antibodies against erythropoietin may contribute to the pathogenesis of this type of anaemia. Patients with autoimmune haemolytic anaemia usually belong to a distinct category, which is associated with anticardiolipin antibodies, thrombosis, thrombocytopenia, and renal disease, often in the context of secondary antiphospholipid syndrome. Autoantibodies, T lymphocytes, and deregulation of the cytokine network can affect bone marrow erythropoiesis, leading to anaemia.