RT Journal Article
SR Electronic
T1 Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go?
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 93
OP 100
DO 10.1136/ard.2005.036905
VO 65
IS 1
A1 M D Smith
A1 D Baeten
A1 A-K Ulfgren
A1 I B McInnes
A1 O Fitzgerald
A1 B Bresnihan
A1 P P Tak
A1 D Veale
A1 on behalf of the OMERACT synovial special interests group
YR 2006
UL http://ard.bmj.com/content/65/1/93.abstract
AB Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation of the site and method of synovial tissue acquisition, methods of tissue processing, and appropriate methods of detection and measurement of cell lineage specific markers and relevant biological proteins is needed.