@article {Zhang495, author = {M-C Zhang and N Misu and H Furukawa and Y Watanabe and M Terada and H Komori and T Miyazaki and M Nose and M Ono}, title = {An epistatic effect of the female specific loci on the development of autoimmune vasculitis and antinuclear autoantibody in murine lupus}, volume = {65}, number = {4}, pages = {495--500}, year = {2006}, doi = {10.1136/ard.2005.040832}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective: To identify the genetic loci regulating the incidence and severity of renal autoimmune vasculitis developed in murine lupus. Methods: Vasculitis of renal arteries was histopathologically evaluated in MRL/Mp-Faslpr (MRL/lpr), C57BL/6-Faslpr (B6/lpr), (MRL/lpr{\texttimes}B6/lpr) F1, and MRL/lpr{\texttimes}(MRL/lpr{\texttimes}B6/lpr) F1 backcross mice. Using genomic DNA samples of the backcross mice, genome-wide scans, association studies, and linkage analyses were carried out based on genotypes of polymorphic microsatellite markers. Correlations of vasculitis grade and levels of various autoantibodies were also evaluated. Results: Two recessive susceptibility loci of the MRL allele were identified on chromosomes 4 and 1, which had previously been defined as the autoimmune related loci termed Arvm1 and Sle-1/Nba2, respectively. The former was epistatic to the latter in a female specific manner. The titre of antinuclear autoantibody (ANA) in IgG class, but not ANA in IgM class or anti-dsDNA in either IgG or IgM class, correlated significantly with vasculitis grade. Conclusions: The present loci have been reported in previous studies using a different set of murine strains, suggesting that they are of importance in the development of autoimmune vasculitis in murine models. The concomitance of autoimmune vasculitis and IgG ANA suggests a shared genetic factor regulating these traits.}, issn = {0003-4967}, URL = {https://ard.bmj.com/content/65/4/495}, eprint = {https://ard.bmj.com/content/65/4/495.full.pdf}, journal = {Annals of the Rheumatic Diseases} }