PT - JOURNAL ARTICLE AU - T Gaber AU - R Dziurla AU - R Tripmacher AU - G R Burmester AU - F Buttgereit TI - Hypoxia inducible factor (HIF) in rheumatology: low O<sub>2</sub>! See what HIF can do! AID - 10.1136/ard.2004.031641 DP - 2005 Jul 01 TA - Annals of the Rheumatic Diseases PG - 971--980 VI - 64 IP - 7 4099 - http://ard.bmj.com/content/64/7/971.short 4100 - http://ard.bmj.com/content/64/7/971.full SO - Ann Rheum Dis2005 Jul 01; 64 AB - Maintenance of oxygen homoeostasis is the basic principle in cell proliferation, differentiation, survival, and function in all higher organisms. The transcription factor, HIF (hypoxia inducible factor) has a central role in oxygen homoeostasis, and is indispensably linked to energy metabolism. Abnormally reduced oxygen concentrations leading to dysfunctional cell metabolism are found in rheumatoid arthritis and hence, knowledge of the molecular adaptive responses to hypoxia and the involvement of HIF in the pathogenesis of RA are interesting.