PT  - JOURNAL ARTICLE
AU  - M Ramos-Casals
AU  - A G Tzioufas
AU  - J Font
TI  - Primary Sjögren’s syndrome: new clinical and therapeutic concepts
AID  - 10.1136/ard.2004.025676
DP  - 2005 Mar 01
TA  - Annals of the Rheumatic Diseases
PG  - 347--354
VI  - 64
IP  - 3
4099  - http://ard.bmj.com/content/64/3/347.short
4100  - http://ard.bmj.com/content/64/3/347.full
SO  - Ann Rheum Dis2005 Mar 01; 64
AB  - Sicca features are the central clinical manifestations of Sjögren’s syndrome (SS), but recent studies have confirmed that primary SS has a systemic expression, including extraglandular manifestations. Patients with a predominantly extraepithelial expression should be managed differently from patients with predominantly periepithelial or sicca limited disease. In coming years treatment will be based on muscarinic agonists for sicca features and immunosuppressive/biological agents for extraglandular features.