RT Journal Article
SR Electronic
T1 <em>CARD15</em> gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn’s disease
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 930
OP 935
DO 10.1136/ard.2004.028837
VO 64
IS 6
A1 D Laukens
A1 H Peeters
A1 D Marichal
A1 B Vander Cruyssen
A1 H Mielants
A1 D Elewaut
A1 P Demetter
A1 C Cuvelier
A1 M Van Den Berghe
A1 P Rottiers
A1 E M Veys
A1 E Remaut
A1 L Steidler
A1 F De Keyser
A1 M De Vos
YR 2005
UL http://ard.bmj.com/content/64/6/930.abstract
AB Background: The association between spondyloarthropathy and Crohn’s disease is well known. A risk for evolution to Crohn’s disease has already been shown in the subgroup of patients with spondyloarthropathy associated with chronic gut inflammation. Objective: To investigate whether the reported polymorphisms in the CARD15 gene, a susceptibility gene for Crohn’s disease, are associated with the presence of preclinical intestinal inflammation observed in spondyloarthropathies. Methods: 104 patients with spondyloarthropathies were studied. All underwent ileocolonoscopy with biopsies between 1983 and 2004. The prevalence of three single nucleotide polymorphisms in the CARD15 gene (R702W, G908R, and 1007fs) was assessed using restriction fragment length polymorphism–polymerase chain reaction (RFLP-PCR); the patients were compared with an ethnically matched Crohn’s disease population and a control population. Results: The carrier frequency of R702W, G908R, or 1007fs variants in the spondyloarthropathy populations (20%) was similar to the control population (17%), but increased to 38% in the spondyloarthropathy subgroup with chronic gut inflammation. This frequency was significantly higher than in the other spondyloarthropathy subgroups (p = 0.001) or the control group (p = 0.006), but not different from the Crohn’s disease group (49%) (NS). This indicates that CARD15 polymorphisms are associated with a higher risk for development of chronic gut inflammation. Conclusions:CARD15 gene polymorphisms clearly identify a subgroup of patients with spondyloarthropathies associated with chronic intestinal inflammation.