RT Journal Article
SR Electronic
T1 Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1155
OP 1158
DO 10.1136/ard.2003.013417
VO 63
IS 9
A1 Hoffman, I E A
A1 Peene, I
A1 Meheus, L
A1 Huizinga, T W J
A1 Cebecauer, L
A1 Isenberg, D
A1 De Bosschere, K
A1 Hulstaert, F
A1 Veys, E M
A1 De Keyser, F
YR 2004
UL http://ard.bmj.com/content/63/9/1155.abstract
AB Objectives: To study associations between antinuclear antibodies (ANA) and signs/symptoms in patients with systemic lupus erythematosus (SLE).Methods: A consecutive cohort of 289 patients with SLE was included; 235 fulfilled ACR criteria for SLE and were further analysed. ANA profiles were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae. An extensive list of signs/symptoms was evaluated.Results: Five clusters of antibodies were defined by cluster analysis: 1—antibodies to SmB, SmD, RNP-A, RNP-C, and RNP-70k; 2—antibodies to Ro52, Ro60, and SSB; 3, 4, and 5—antibodies to ribosomal P, histones and dsDNA, respectively. Significant associations (p⩽0.01) were found between anti-RNP-70k, anti-RNP-A, anti-RNP-C and Raynaud’s phenomenon, between anti-RNP-A, anti-RNP-70k and leucopenia, and between anti-RNP-A, anti-RNP-C and a lower prevalence of urine cellular casts. Anti-SSA, anti-SSB were associated with xerostomia, and anti-SSB with pericarditis. Antibodies to ribosomal P were associated with haemolytic anaemia, leucopenia, and alopecia. Patients with anti-dsDNA antibodies had a higher risk for cellular casts and a lower risk for photosensitivity. Antihistone antibodies were associated with arthritis.Conclusions: In a large and consecutive cohort of patients with SLE, clusters of antibodies were identified. Previously reported associations of antibodies with symptoms were confirmed and new associations found.