RT Journal Article
SR Electronic
T1 A fibrin based model for rheumatoid synovitis
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 1135
OP 1138
DO 10.1136/ard.2003.011767
VO 62
IS 12
A1 O Sánchez-Pernaute
A1 R Largo
A1 E Calvo
A1 M A Alvarez-Soria
A1 J Egido
A1 G Herrero-Beaumont
YR 2003
UL http://ard.bmj.com/content/62/12/1135.abstract
AB Intracavitary fibrin clots may initiate pannus formation and the immunopathology of RA. Two critical steps, probably host dependent, may determine the development of RA: an altered regulation of extravascular haemostasis or an aberrant reactivity of synovial fibroblasts to the adhered fibrin clots. Current treatments for RA target events downstream of fibrin deposition, perhaps agents acting at an earlier stage should be tried.