TY - JOUR T1 - A fibrin based model for rheumatoid synovitis JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 1135 LP - 1138 DO - 10.1136/ard.2003.011767 VL - 62 IS - 12 AU - O Sánchez-Pernaute AU - R Largo AU - E Calvo AU - M A Alvarez-Soria AU - J Egido AU - G Herrero-Beaumont Y1 - 2003/12/01 UR - http://ard.bmj.com/content/62/12/1135.abstract N2 - Intracavitary fibrin clots may initiate pannus formation and the immunopathology of RA. Two critical steps, probably host dependent, may determine the development of RA: an altered regulation of extravascular haemostasis or an aberrant reactivity of synovial fibroblasts to the adhered fibrin clots. Current treatments for RA target events downstream of fibrin deposition, perhaps agents acting at an earlier stage should be tried. ER -