PT  - JOURNAL ARTICLE
AU  - A R Lorenzi
AU  - A H Johnson
AU  - G Davies
AU  - A Gough
TI  - Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide
AID  - 10.1136/ard.60.8.796
DP  - 2001 Aug 01
TA  - Annals of the Rheumatic Diseases
PG  - 796--798
VI  - 60
IP  - 8
4099  - http://ard.bmj.com/content/60/8/796.short
4100  - http://ard.bmj.com/content/60/8/796.full
SO  - Ann Rheum Dis2001 Aug 01; 60
AB  - A case of severe, transfusion dependent anaemia in a 72 year old woman, which on endoscopy was found to be due to gastric antral vascular ectasia (GAVE), is reported. Repeated endoscopic sclerotherapy was ineffective. She subsequently developed Raynaud's phenomenon and on further investigation was found to have classical systemic sclerosis with lung involvement. Treatment with pulses of intravenous methylprednisolone and cyclophosphamide resulted in significant improvement in her pulmonary function tests and skin score. Coincidentally, her haemoglobin stabilised and further endoscopic examinations were normal. This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.