TY - JOUR T1 - Severe atherosclerotic changes, including aortic occlusion, associated with hyperhomocysteinaemia and antiphospholipid antibodies JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 699 LP - 701 DO - 10.1136/ard.60.7.699 VL - 60 IS - 7 AU - P E Spronk AU - E H Overbosch AU - N H Schut Y1 - 2001/07/01 UR - http://ard.bmj.com/content/60/7/699.abstract N2 - Three patients are described with severe systemic atherosclerosis, including aortic occlusion, in the presence of a spectrum of risk factors, including hypercholesterolaemia, hypertension, a positive family history of cardiovascular problems, and hyperhomocysteinaemia. In all three patients high levels of anticardiolipin antibodies were found. The possible pathogenic role of antiphospholipid antibodies in atherosclerosis in the context of hyperhomocysteinaemia in these patients is discussed. ER -