TY - JOUR T1 - Human immunodeficiency virus associated spondyloarthropathy: pathogenic insights based on imaging findings and response to highly active antiretroviral treatment JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 696 LP - 698 DO - 10.1136/ard.60.7.696 VL - 60 IS - 7 AU - D McGonagle AU - S Reade AU - H Marzo-Ortega AU - W Gibbon AU - P O'Connor AU - A Morgan AU - R Melsom AU - E Morgan AU - P Emery Y1 - 2001/07/01 UR - http://ard.bmj.com/content/60/7/696.abstract N2 - The pathogenesis of human immunodeficiency virus (HIV) associated spondyloarthropathy (SpA) is poorly understood. In this case report a patient is described with severe HIV associated reactive arthritis, who on magnetic resonance imaging and sonographic imaging of inflamed knees had extensive polyenthesitis and adjacent osteitis. The arthritis deteriorated despite conventional antirheumatic treatment, but improved dramatically after highly active antiretroviral treatment, which was accompanied by a significant rise in CD4 T lymphocyte counts. The implications of the localisation of pathology and effect of treatment for pathogenic models of SpA and rheumatoid arthritis in the setting of HIV infection are discussed. ER -