RT Journal Article
SR Electronic
T1 Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 132
OP 134
DO 10.1136/ard.59.2.132
VO 59
IS 2
A1 Richard J Stratton
A1 Lucie Pompon
A1 John G Coghlan
A1 Jeremy D Pearson
A1 Carol M Black
YR 2000
UL http://ard.bmj.com/content/59/2/132.abstract
AB OBJECTIVE To investigate the expression of thrombomodulin in scleroderma associated pulmonary hypertension.METHODS Soluble thrombomodulin (sTM), was measured in plasma samples from 34 scleroderma patients shown to have pulmonary hypertension at echocardiogram, and comparison drawn against samples from 38 scleroderma control patients, and 20 healthy controls. Serial measurements of sTM were performed in the 34 patients with scleroderma associated pulmonary hypertension to investigate possible changes in sTM concentration with progression of the condition.RESULTS Mean sTM was raised in scleroderma associated pulmonary hypertension when compared with scleroderma controls (mean sTM 65.4 ng/mlv 43.3 ng/ml, p<0.05), and when compared with healthy controls (mean sTM 38.1 ng/ml, p<0.05). There was no significant difference between mean sTM in scleroderma controls and healthy controls. Mean sTM concentration did not change with progression of pulmonary hypertension.CONCLUSION Plasma sTM is raised in scleroderma associated pulmonary hypertension. The pathogenesis of scleroderma associated pulmonary hypertension may be distinct from the pathogenesis of other forms of pulmonary vascular disease.