@article {Brown268, author = {M A Brown and K D Pile and L G Kennedy and A Calin and C Darke and J Bell and B P Wordsworth and F Corn{\'e}lis}, title = {HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom.}, volume = {55}, number = {4}, pages = {268--270}, year = {1996}, doi = {10.1136/ard.55.4.268}, publisher = {BMJ Publishing Group Ltd}, abstract = {OBJECTIVE: To investigate the HLA class I associations of ankylosing spondylitis (AS) in the white population, with particular reference to HLA-B27 subtypes. METHODS: HLA-B27 and -B60 typing was performed in 284 white patients with AS. Allele frequencies of HLA-B27 and HLA-B60 from 5926 white bone marrow donors were used for comparison. HLA-B27 subtyping was performed by single strand conformation polymorphism (SSCP) in all HLA-B27 positive AS patients, and 154 HLA-B27 positive ethnically matched blood donors. RESULTS: The strong association of HLA-B27 and AS was confirmed (odds ratio (OR) 171, 95\% confidence interval (CI) 135 to 218; p \< 10(-99)). The association of HLA-B60 with AS was confirmed in HLA-B27 positive cases (OR 3.6, 95\% CI 2.1 to 6.3; p \< 5 x 10(-5)), and a similar association was demonstrated in HLA-B27 negative AS (OR 3.5, 95\% CI 1.1 to 11.4; p \< 0.05). No significant difference was observed in the frequencies of HLA-B27 allelic subtypes in patients and controls (HLA-B*2702, three of 172 patients v five of 154 controls; HLA-B*2705, 169 of 172 patients v 147 of 154 controls; HLA-B*2708, none of 172 patients v two of 154 controls), and no novel HLA-B27 alleles were detected. CONCLUSION: HLA-B27 and -B60 are associated with susceptibility to AS, but differences in HLA-B27 subtype do not affect susceptibility to AS in this white population.}, issn = {0003-4967}, URL = {https://ard.bmj.com/content/55/4/268}, eprint = {https://ard.bmj.com/content/55/4/268.full.pdf}, journal = {Annals of the Rheumatic Diseases} }