PT  - JOURNAL ARTICLE
AU  - Takeuchi, F
AU  - Nakano, K
AU  - Nabeta, H
AU  - Hong, G H
AU  - Kuwata, S
AU  - Ito, K
TI  - Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE.
AID  - 10.1136/ard.55.12.924
DP  - 1996 Dec 01
TA  - Annals of the Rheumatic Diseases
PG  - 924--926
VI  - 55
IP  - 12
4099  - http://ard.bmj.com/content/55/12/924.short
4100  - http://ard.bmj.com/content/55/12/924.full
SO  - Ann Rheum Dis1996 Dec 01; 55
AB  - OBJECTIVE: To determine how polymorphism of transporter associated with antigen processing 1 and 2 (TAP1 and 2) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Japanese patients. METHODS: TAP1 and TAP2 typing was carried out in 52 Japanese patients with SLE and 95 normal subjects by the PCR-RFLP (restriction fragment length polymorphism) method. HLA-DR typing and HLA-DRB1*15 genotyping were carried out by the PCR method and PCR-SSCP (single stranded DNA conformation polymorphism) method, respectively. RESULTS: No particular TAP 1 allele was associated with Japanese SLE or with immunological subgroup of SLE. TAP2H showed a tendency towards increased frequency in SLE (5.8% v 0% in control), but the corrected P value was not significant. No other particular association of TAP2 allele was observed. Furthermore, these was no evidence for linkage disequilibrium between any TAP1/TAP2 alleles and HLA-DRB1*1501--which is reported to be weakly but significantly association with Japanese SLE--in either the normal control or the SLE patient group. CONCLUSIONS: Neither the TAP1 nor the TAP2 gene appears to determine disease susceptibility to SLE in Japanese, and these results are in keeping with those reported in Caucasian SLE patients.