RT Journal Article
SR Electronic
T1 Sister chromatid exchange analysis in the lymphocytes of patients with ankylosing spondylitis
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 275
OP 277
DO 10.1136/ard.56.4.275
VO 56
IS 4
A1 Sinan Sönmez
A1 Kazım Şenel
A1 Sıtkı Öztaş
A1 Akın Erdal
A1 Lale Cerrahoğlu
YR 1997
UL http://ard.bmj.com/content/56/4/275.abstract
AB OBJECTIVE This study investigated whether any genomic change occurs in DNA level in ankylosing spondylitis (AS) by measuring sister chromatid exchange (SCE) frequency.METHODS SCE frequency was detected on metaphase chromosomes obtained from peripheral blood lymphocyte cultures in 15 patients diagnosed as having AS. SCE values were also obtained from 15 healthy subjects as a control group. SCE frequencies were detected from metaphases obtained from standard blood cultures by using bromodeoxyuridine and staining by Giemsa.RESULTS SCE frequencies of AS were statistically higher than those of the control group (p<0.005).CONCLUSION These results suggest that genetic factors may play a more important part than realised in the aetiology of AS.