RT Journal Article
SR Electronic
T1 Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 25
OP 29
DO 10.1136/ard.55.1.25
VO 55
IS 1
A1 R Hirsch
A1 M Lethbridge-Cejku
A1 W W Scott, Jr
A1 R Reichle
A1 C C Plato
A1 J Tobin
A1 M C Hochberg
YR 1996
UL http://ard.bmj.com/content/55/1/25.abstract
AB OBJECTIVE--To examine the association between hand and knee osteoarthritis (OA) in a community based population. METHODS--Radiographs of 695 participants aged > or = 40 years in the Baltimore Longitudinal Study of Aging were read for changes of OA, using Kellgren-Lawrence grade > or = 2 as the case definition. RESULTS--Logistic regression analyses, adjusting for age, gender and body mass index, revealed a significant association between OA in the knee and the following joint groups: distal and proximal interphalangeal (DIP, PIP) and Hand2 (OA in two or more hand joint groups) for grade 2-4 and grade 3-4 disease, and the first carpometacarpal (CMC1) joint for grade 3-4 disease. CONCLUSION--There is an association between OA in hand sites and the knee. The strength of the associations increases with increasing disease severity. For the PIP site, there is a trend toward increasing strength of association for increasing numbers of affected joints and bilateral disease.