PT  - JOURNAL ARTICLE
AU  - Hocini, H
AU  - Iscaki, S
AU  - Benlahrache, C
AU  - Vitalis, L
AU  - Chevalier, X
AU  - Larget-Piet, B
AU  - Bouvet, J P
TI  - Increased levels of serum IgA as IgA1 monomers in ankylosing spondylitis.
AID  - 10.1136/ard.51.6.790
DP  - 1992 Jun 01
TA  - Annals of the Rheumatic Diseases
PG  - 790--792
VI  - 51
IP  - 6
4099  - http://ard.bmj.com/content/51/6/790.short
4100  - http://ard.bmj.com/content/51/6/790.full
SO  - Ann Rheum Dis1992 Jun 01; 51
AB  - The various subsets of serum IgA were determined in 43 patients with ankylosing spondylitis to investigate the putative mucosal origin of increased IgA concentrations in this disease. Total IgA was shown to be increased and weakly correlated with the erythrocyte sedimentation rate (ESR). In contrast, although the mean concentration (but not the median) of secretory IgA (SIgA) was slightly increased, no correlation was found with total IgA nor the ESR. Moreover, molecular sieving of nine serum samples selected for their high concentrations of total IgA, and absorption with insoluble jacalin showed these immunoglobulins to be essentially monomers of the IgA1 subclass. These results are consistent with a non-secretory origin of the increase of serum IgA, which must be ascribed to the central immune system.