TY - JOUR T1 - Primary Sjögren's syndrome with antibodies to HTLV-I: clinical and laboratory features. JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 769 LP - 776 DO - 10.1136/ard.51.6.769 VL - 51 IS - 6 AU - K Eguchi AU - N Matsuoka AU - H Ida AU - M Nakashima AU - M Sakai AU - S Sakito AU - A Kawakami AU - K Terada AU - H Shimada AU - Y Kawabe Y1 - 1992/06/01 UR - http://ard.bmj.com/content/51/6/769.abstract N2 - The prevalence of antibodies to human T lymphotropic virus type I (HTLV-I) was studied in patients with primary Sjögren's syndrome. Thirteen of 36 serum samples were positive by enzyme linked immunosorbent assay (ELISA) and particle agglutination assay for antibodies to HTLV-I and were confirmed by western blotting. The presence of antibodies to HTLV-I may signify an HTLV-I carrier state. These patients had a high occurrence of extraglandular manifestations such as uveitis, myopathy, and recurrent high fever compared with patients who did not have antibodies to HTLV-I. Patients with antibodies to HTLV-I had an increased spontaneous proliferation of peripheral blood mononuclear cells compared with those without the antibodies. The proportions of activated and memory T cells (HLA-DR+ CD3+, CD25+ CD3+, and CD29+ CD4+ cells) were higher in HTLV-I carriers than in non-carriers. The presence of antibodies to HTLV-I in some patients with primary Sjögren's syndrome suggests that HTLV-I may cause primary Sjögren's syndrome or its extraglandular manifestations, or both. ER -