PT  - JOURNAL ARTICLE
AU  - Jobanputra, P
AU  - Choy, E H
AU  - Kingsley, G H
AU  - Sieper, J
AU  - Palacios-Boix, A A
AU  - Heinegård, D
AU  - Panayi, G S
TI  - Cellular immunity to cartilage proteoglycans: relevance to the pathogenesis of ankylosing spondylitis.
AID  - 10.1136/ard.51.8.959
DP  - 1992 Aug 01
TA  - Annals of the Rheumatic Diseases
PG  - 959--962
VI  - 51
IP  - 8
4099  - http://ard.bmj.com/content/51/8/959.short
4100  - http://ard.bmj.com/content/51/8/959.full
SO  - Ann Rheum Dis1992 Aug 01; 51
AB  - Cellular immunity to cartilage proteoglycans may be responsible for sustaining chronic inflammation in ankylosing spondylitis. This hypothesis was examined by measuring peripheral blood and synovial fluid mononuclear cell proliferation in five preparations of human cartilage proteoglycan monomer in vitro. Peripheral blood mononuclear cells from 25 patients and synovial fluid mononuclear cells from five patients were compared with those from normal and disease control subjects matched for age. No significant differences were found between the three groups. This suggests that autoimmune responses to cartilage proteoglycans are unlikely to play a significant part in the pathogenesis of ankylosing spondylitis.