TY - JOUR T1 - Urinary excretion of pyridinium crosslinks of collagen in patients with osteoporosis and the effects of bone fracture. JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 648 LP - 651 DO - 10.1136/ard.51.5.648 VL - 51 IS - 5 AU - A M McLaren AU - L D Hordon AU - H A Bird AU - S P Robins Y1 - 1992/05/01 UR - http://ard.bmj.com/content/51/5/648.abstract N2 - Values for the urinary excretion of pyridinium crosslinks of collagen, pyridinoline and deoxypyridinoline, in a group of 30 elderly women with femoral fractures associated with osteoporosis and a group of 20 women without recent fracture but with overt or suspected osteoporosis were compared with 27 control subjects matched for age. Relative to the control group, the excretion of the crosslinks was significantly higher in the group with fractures and the group with osteoporosis. Fractures contributed markedly to the excretion of pyridinium crosslinks as the patients with fractures showed significantly higher excretion of pyridinoline and deoxypyridinoline than the group without recent fractures. This was confirmed by the fact that excretion of pyridinium crosslinks in patients with accidental bone fractures was significantly higher than for healthy control subjects matched for age and sex. The crosslinks appear to provide valid indices of bone resorption, but the effects of bone fracture must be considered in the clinical application of this technique. ER -