RT Journal Article
SR Electronic
T1 Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 600
OP 603
DO 10.1136/ard.51.5.600
VO 51
IS 5
A1 Alarcón, G S
A1 Castañeda, O
A1 Nair, M G
A1 Ferrándiz, M
A1 Koopman, W J
A1 Krumdieck, C L
YR 1992
UL http://ard.bmj.com/content/51/5/600.abstract
AB A 15 week double blind controlled trial of methotrexate and 10-deazaaminopterin for the treatment of rheumatoid arthritis (RA) was performed in 26 patients. Significant improvement in all measured clinical parameters was observed in the two patient groups. The drugs were well tolerated; only one patient (10-deazaaminopterin) withdrew from the study because of side effects. It is concluded that, in the context of this relatively short clinical trial, 10-deazaaminopterin is at least as beneficial as methotrexate in the treatment of RA.