PT  - JOURNAL ARTICLE
AU  - Alarcón, G S
AU  - Castañeda, O
AU  - Nair, M G
AU  - Ferrándiz, M
AU  - Koopman, W J
AU  - Krumdieck, C L
TI  - Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
AID  - 10.1136/ard.51.5.600
DP  - 1992 May 01
TA  - Annals of the Rheumatic Diseases
PG  - 600--603
VI  - 51
IP  - 5
4099  - http://ard.bmj.com/content/51/5/600.short
4100  - http://ard.bmj.com/content/51/5/600.full
SO  - Ann Rheum Dis1992 May 01; 51
AB  - A 15 week double blind controlled trial of methotrexate and 10-deazaaminopterin for the treatment of rheumatoid arthritis (RA) was performed in 26 patients. Significant improvement in all measured clinical parameters was observed in the two patient groups. The drugs were well tolerated; only one patient (10-deazaaminopterin) withdrew from the study because of side effects. It is concluded that, in the context of this relatively short clinical trial, 10-deazaaminopterin is at least as beneficial as methotrexate in the treatment of RA.