RT Journal Article
SR Electronic
T1 Effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 631
OP 633
DO 10.1136/ard.50.9.631
VO 50
IS 9
A1 Yamamoto, T
A1 Moriwaki, Y
A1 Takahashi, S
A1 Suda, M
A1 Higashino, K
YR 1991
UL http://ard.bmj.com/content/50/9/631.abstract
AB The effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol were investigated. Pyrazinamide decreased the mean (SEM) fractional clearance of oxypurinol from 19.2 (2.1) to 8.8 (1.5). Probenecid increased the fractional clearance of oxypurinol from 14.1 (3.5) to 24.8 (4.1). Benzbromarone increased the fractional clearance of oxypurinol from 15.6 (2.3) to 33.8 (2.8). These results suggest that oxypurinol may be secreted by 'an organic acid system' and that oxypurinol is reabsorbed at a putative postsecretory site of the renal tubules.