RT Journal Article
SR Electronic
T1 Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 677
OP 679
DO 10.1136/ard.50.10.677
VO 50
IS 10
A1 Chambers, R E
A1 Hutton, C W
A1 Dieppe, P A
A1 Whicher, J T
YR 1991
UL http://ard.bmj.com/content/50/10/677.abstract
AB The responses of C reactive protein, measured by radial immunodiffusion and radioimmunoassay, and serum amyloid A protein, measured by radial immunodiffusion, were compared in eight subjects with inflammation induced experimentally by intradermal injection of monosodium urate crystals. A significant increase in serum amyloid A was noted after a lag phase of eight hours, the increase in median concentration at 48 hours being about eightfold. A parallel but less marked increase was found in C reactive protein when measured by radioimmunoassay (fourfold increase in median concentration at 48 hours) after a small but significant decrease during the lag phase. The changes in C reactive protein remained within the reference range and were not detectable by radial immunodiffusion.