PT  - JOURNAL ARTICLE
AU  - Chambers, R E
AU  - Hutton, C W
AU  - Dieppe, P A
AU  - Whicher, J T
TI  - Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation.
AID  - 10.1136/ard.50.10.677
DP  - 1991 Oct 01
TA  - Annals of the Rheumatic Diseases
PG  - 677--679
VI  - 50
IP  - 10
4099  - http://ard.bmj.com/content/50/10/677.short
4100  - http://ard.bmj.com/content/50/10/677.full
SO  - Ann Rheum Dis1991 Oct 01; 50
AB  - The responses of C reactive protein, measured by radial immunodiffusion and radioimmunoassay, and serum amyloid A protein, measured by radial immunodiffusion, were compared in eight subjects with inflammation induced experimentally by intradermal injection of monosodium urate crystals. A significant increase in serum amyloid A was noted after a lag phase of eight hours, the increase in median concentration at 48 hours being about eightfold. A parallel but less marked increase was found in C reactive protein when measured by radioimmunoassay (fourfold increase in median concentration at 48 hours) after a small but significant decrease during the lag phase. The changes in C reactive protein remained within the reference range and were not detectable by radial immunodiffusion.